Material Safety Data Sheet

N,N-Dimethylformamide, 99%

ACC# 95221

MSDS Name: N,N-Dimethylformamide, 99%

Catalog Numbers: AC116220000, AC116220010, AC116220025, AC116220250

Synonyms: N,N-Dimethylmethanamide; DMF; DMFA.

Company Identification: Acros Organics N.V., One Reagent Lane, Fair Lawn , NJ 07410

For information in North America, call: 1-800-ACROS-01

For emergencies in the US , call CHEMTREC: 1-800-424-9300

Hazard Symbols : T
Risk Phrases : 20/21 36 61

EMERGENCY OVERVIEW

Appearance: clear, colorless liquid. Flash Point: 57 deg C. Warning! Causes respiratory tract irritation. May cause digestive tract irritation with nausea, vomiting, and diarrhea. Causes eye and skin irritation. This substance has caused adverse reproductive and fetal effects in animals. May cause liver and kidney damage. Combustible liquid and vapor. Potential cancer hazard.
Target Organs: Kidneys, liver.


Potential Health Effects

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Notes to Physician: Treat symptomatically and supportively.

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.

Extinguishing Media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Flash Point : 57 deg C ( 134.60 deg F)

Autoignition Temperature: 445 deg C ( 833.00 deg F)

Explosion Limits, Lower: 2.2

Upper: 15.2

NFPA Rating: (estimated) Health: 2; Flammability: 2; Instability: 0

General Information: Use proper personal protective equipment as indicated in Section 8.

Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Do not flush into a sewer. Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation.

Handling: Wash thoroughly after handling. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not ingest or inhale. Use with adequate ventilation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits

OSHA Vacated PELs: N,N-Dimethylformamide: 10 ppm TWA; 30 mg/m3 TWA

Personal Protective Equipment

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.

Skin: Wear appropriate protective gloves to prevent skin exposure.

Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Physical State : Liquid
Appearance: clear, colorless
Odor: Faint, amine odor.
pH: 6 - 8 @ 20% aq.sol.
Vapor Pressure: 4.9 mbar @ 20 C
Vapor Density: 2.5 (air=1)
Evaporation Rate: 0.17 (butylacetate=1)
Viscosity: 0.8 mPas @ 20 C
Boiling Point: 153 deg C
Freezing/Melting Point: 61 deg C
Decomposition Temperature: Not available.
Solubility: Completely soluble in water.
Specific Gravity/Density: 0.9450
Molecular Formula: C₃H₇NO
Molecular Weight: 73.0551

Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions.

Conditions to Avoid: Mechanical shock, incompatible materials, ignition sources, excess heat, temperatures above 55°C.

Incompatibilities with Other Materials: Carbontetrachloride, violent reaction with halogens, iron, oxidizing materials, chlorinated hydrocarbons, isocyanates, nitrates, organic materials, phenols, ammonia, anhydrides.

Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.

Hazardous Polymerization: Will not occur.

RTECS#:

CAS# 68-12-2: LQ2100000

LD50/LC50:

CAS# 68-12-2:
Inhalation, mouse: LC50 = 9400 mg/m3/2H;
Oral, mouse: LD50 = 2900 mg/kg;
Oral, rabbit: LD50 = 5 gm/kg;
Oral, rat: LD50 = 2800 mg/kg;
Skin, rabbit: LD50 = 4720 mg/kg;<BR.

Carcinogenicity:
CAS# 68-12-2:

ACGIH: A4 - Not Classifiable as a Human Carcinogen

IARC: IARC Group 3 - not classifiable

Epidemiology: Experimental reproductive effects have been reported.

Teratogenicity: No information available.

Reproductive Effects: Similar compounds have shown reproductive effects.

Neurotoxicity: No information available.

Mutagenicity: Reported non-mutagenic in a large number of assays using whole animals, cultured mammalian cells, yeast and bacteria; including dominant lethal tests in rats, micronucleus test and sperm abnormality test.

Other Studies: See actual entry in RTECS for complete information.

Ecotoxicity: No data available. Damage to fish: Gold oland test: 18 hrs LC50: 500 mg/l

Environmental: DMF is expected to biodegrade rapidly in the environment and should be highly mobile in soil. In aquatic systems, DMF is not expected to partition from the water column to organic matter contained in sediments and suspended solids or bioconcentrate in aquatic organisms.

Physical: The vapor-phase reaction with photochemically produced hydroxyl radicals (half-life of 2 hours) is likely to be an important fate process.

Other: No information available.

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.

RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 68-12-2 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 68-12-2: Effective Date: 4/13/89; Sunset Date: 12/19/95
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.

SARA
CERCLA Hazardous Substances and corresponding RQs
CAS# 68-12-2: 100 lb final RQ; 45.4 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 68-12-2: acute, flammable.
Section 313
This material contains N,N-Dimethylformamide (CAS# 68-12-2, 99%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.

Clean Air Act:
CAS# 68-12-2 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.

Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.

OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.

STATE
CAS# 68-12-2 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts .
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 20/21 Harmful by inhalation and in contact with skin.
R 36 Irritating to eyes.
R 61 May cause harm to the unborn child.

Safety Phrases:
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.

WGK (Water Danger/Protection)
CAS# 68-12-2: 1

Canada - DSL/NDSL
CAS# 68-12-2 is listed on Canada 's DSL List.

Canada - WHMIS
This product has a WHMIS classification of B3, D2B.

Canadian Ingredient Disclosure List
CAS# 68-12-2 is listed on the Canadian Ingredient Disclosure List.

Exposure Limits

CAS# 68-12-2: OEL-AUSTRALIA:TWA 10 ppm (30 mg/m3);Skin OEL-BELGIUM:TWA 10 ppm (30 mg/m3);Skin OEL-CZECHOSLOVAKIA:TWA 30 mg/m3;STEL 60 mg/m3 OEL-DENMARK:TWA 10 ppm (30 mg/m3);Skin OEL-FINLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3);Skin OEL-FRANCE:TWA 10 ppm (30 mg/m3);Skin OEL-GERMANY:TWA 20 ppm (60 mg/m3);Skin OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin OEL-JAPAN:TWA 10 ppm (30 mg/m3);Skin OEL-THE NETHERLANDS:TWA 10 ppm (30 mg/m3);Skin OEL-THE PHILIPPINES:TWA 10 ppm (30 mg/m3);Skin OEL-POLAND:TWA 10 mg/m3 OEL-RUSSIA:TWA 10 ppm;STEL 10mg/m3;Skin OEL-SWEDEN:TWA 10 ppm (30 mg/m3);STEL 15 ppm (45 mg/m3);Skin OEL-SWITZERLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm;Skin OEL-TURKEY:TWA 10 ppm (30 mg/m3);Skin OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);STEL 20 ppm;Skin OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV

MSDS Creation Date: 2/17/1999
Revision #3 Date: 12/03/2002

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.

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